The National Patient Safety Goals (NPSGs) have become a critical method by which the Joint Commission promotes and enforces major changes in patient safety in thousands of participating health care organizations in the United States and around the world. While the 2009 NPSGs include new regulations targeting the spread of infections due to multidrug-resistant organisms, catheter-related bloodstream infections (CRBSI), and surgical site infections (SSI), the 2010 version is highlighted by revisions to existing goals rather than new ones created. For example, medication reconciliation is no longer part of the scoring during on-site surveys (though still being evaluated) while the Joint Commission further evaluates this goal with additional literature reviews and expert input. The Universal Protocol to prevent wrong site, procedure, and person surgery have also been modified for 2010, based on feedback received by the Joint Commission. The 2010 NPSGs are now available for review.