Skip Navigation
The Collection >
Adverse drug events in ambulatory care. Classic icon
Gandhi TK, Weingart SN, Borus J, et al. N Engl J Med. 2003;348:1556-1564.

This prospective cohort study evaluated more than 1200 outpatient prescriptions, surveyed patients, and conducted a chart review during a 4-week period. Investigators discovered that 25% of patients experienced an adverse drug event with selective serotonin-reuptake inhibitors, beta blockers, angiotensin-converting-enzyme inhibitors, and nonsteroidal anti-inflammatory medication classes the most frequently implicated. The rate of ADEs in this study approached 27 per 100 patients, a rate that quadruples those estimated in the inpatient setting. The authors suggest a number of preventive strategies that may reduce the nearly one third of events that were deemed preventable.

PubMed citation icon indicating hyperlink to external website
Free full text icon indicating hyperlink to external website
white box
Related Resources
Epidemiology of medical error.
Weingart SN, Wilson RM, Gibberd RW, Harrison B. BMJ. 2000;320:774-777.
Risk of unintentional overdose with non-prescription acetaminophen products.
Wolf MS, King J, Jacobson K, et al. J Gen Intern Med. 2012;27:1587-1593.
Signal and noise: applying a laboratory trigger tool to identify adverse drug events among primary care patients.
Brenner S, Detz A, López A, Horton C, Sarkar U. BMJ Qual Saf. 2012;21:670-675.
The effects of electronic prescribing by community-based providers on ambulatory medication safety.
Abramson EL, Pfoh ER, Barrón Y, Quaresimo J, Kaushal R. Jt Comm J Qual Patient Saf. 2013;39:545-552.
View all related resources...
white box
Download: Adobe Reader   email icon Email
tan box
Find Related Resources by...
Resource Type   
Setting of Care  
Target Audience  
Safety Target  
Error Types  
white box